Metal-Catalysed A3 Coupling Methodologies: Classification and Visualisation

The multicomponent reaction of aldehydes, amines, and alkynes, known as A3 coupling, yields propargylamines, a valuable organic scaffold, has received significant interest attention in the last years. In order to fully realise potential metal-based catalytic protocols that facilitate this transformation, we summarise substrates, situ well-characterised synthetic methods provide scaffold attempt monumental classification considering several variables (Metal, Coordinating atom(s), Ligand type name, in-situ or well-characterised, co-catalyst, catalyst ligand Loading (mol%), solvent, volume, atmosphere, temperature, microwave, time, yield, selectivity (e.e. d.r.), substrate functionality, loading (amines, alkynes), use molecular sieves). This pioneering work creates database contains 2376 entries allows us produce graphs better visualise their impact on reaction.